Forskolin is able to increase activity of AdenylateCyclase in skeletal muscle. Forskolin, in vitro at concentrations of 1uM, has been shown to increase electical-stimulated skeletal muscle contractility in the mouse diaphragm. Through increasing cAMP, it has been speculated that Forskolin can increase muscle protein synthesis by activating PI3K independent of the insulin receptor and that this reaction is subject to desensitization. The theorized mechanims of this is increasing cAMP levels, inducing PKA activity which acts on the ryanodine receptor and increases Ca2+ efflux from the sarcoplasmic reticulum.
Forskolin has been implicated in vivo in reducing insulin's effects on the mTOR/Aktpathway in skeletal muscle. Specifically, Forskolin appeared to reduce insulin's ability to phosphorylate and similar results were seen when looking at 4EBP1, with mTOR and S6K1 unaffected by all treatments. Although biological plausibility exists, no studies have been conducted on Pure Forskolin Review and muscle contraction in vivo.This may also be downstream of cAMP, as it is seen in adipocytes as cAMP is known to adversely influence GLUT4 translocation via its PROMOTER, and also in muscle cells.Forskolin is also able to inhibit myocyte GLUT4 translocation in vitro, and GLUT1 to a lesser degree. Possibly through a myokine called Myonectin. For more details about Pure Forskolin visit our website.